There are three staging systems currently in use for pleural mesothelioma and each one measures somewhat different variables; peritoneal mesothelioma is not staged.
Stage I : Mesothelioma is present in the right or left pleura and may also involve the diaphragm on the same side.
Stage II : Mesothelioma invades the chest wall or involves the esophagus, heart, or pleura on both sides. Lymph nodes in the chest may also be involved.
Stage III : Mesothelioma has penetrated through the diaphragm into the lining of the abdominal cavity or peritoneum. Lymph nodes beyond those in the chest may also be involved.
Stage IV : There is evidence of metastasis or spread through the bloodstream to other organs. ( Butchart System )
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